![]() Factors II and V deficiency were identified in the 1940s. Alfredo Pavlovsky, a doctor in Buenos Aires, Argentina, distinguished two types of hemophilia in his lab-A and B.įactor I deficiency was first described in 1920. In 1957 Inga Marie Nilsson and researchers at the Malmo University Hospital in Sweden determined that VWD was caused by low levels or deficient von Willebrand factor. It was later named von Willebrand disease. In 1926 Finnish physician Erik von Willebrand published a paper describing what he called “pseudohemophilia,” a bleeding disorder affecting men and women equally. Schonlein, are credited with coining the term “haemorrhaphilia” for the condition, later shorted to “haemophilia.” Then in 1828, Friedrich Hopff, a student at the University of Zurich, and his professor Dr. Otto called the males “bleeders.” In 1813, John Hay published a paper in the New England Journal of Medicine proposing that affected men could pass the trait for a bleeding disorder to their unaffected daughters. He traced the disease back to a female ancestor living in Plymouth, New Hampshire, in 1720. In 1803, John Conrad Otto, a Philadelphia physician, was the first to publish an article recognizing that a hemorrhagic bleeding disorder primarily affected men, and ran in certain families. Abulcasis, or Abu Khasim, a 10 th century Arabian physician, described families whose male relatives died from uncontrolled bleeding after trauma. The New Testament of the Bible mentioned a woman who had hemorrhaged for 12 years, before touching the hem of Jesus’ garment, when she was healed. The Talmud, a collection of Jewish rabbinical writings on laws and traditions, from the 2 nd century AD, stated that baby boys did not have to be circumcised if two of their brothers had previously died from the procedure. Incidences of excessive or abnormal bleeding were first recorded hundreds of years ago.
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